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Article

Behavioral impairment of APP(V717F) mice in fear conditioning: is it only cognition?

Behavioural brain research - 15 Nov 2002

Gerlai Robert, Fitch Thomas, Bales Kelly R, Gitter Bruce D

Abstract excerpt

Alzheimer's Disease (AD) is a devastating human neurodegenerative disorder associated with progressive deterioration of cognitive abilities. The APP(V717F) mouse, an animal model of AD showing robust overexpression of the human amyloid precursor protein (APP) carrying the mutation 717 V --> F, was also shown to exhibit learning and memory performance deficits. However, AD patients suffer from other abnormalities...

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Identifiers

PMID: 12429413
DOI: 10.1016/s0166-4328(02)00198-5

Genes

APP

Variants

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