Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic BACE-1 Inhibitor Administration in TASTPM Mice (APP KM670/671NL and PSEN1 M146V Mutation): An EEG Study.

International journal of molecular sciences - 28 Nov 2020

Lopez Susanna, Del Percio Claudio, Forloni Gianluigi, Frasca Angelisa, Drinkenburg Wilhelmus H, Lizio Roberta, Noce Giuseppe, Ferri Raffaele, Soricelli Andrea, Stocchi Fabrizio, Vacca Laura, Bordet Règis, Richardson Jill C, Babiloni Claudio

Abstract excerpt

OBJECTIVE: In this exploratory study, we tested whether electroencephalographic (EEG) rhythms may reflect the effects of a chronic administration (4 weeks) of an anti-amyloid β-site amyloid precursor protein (APP) cleaving enzyme 1 inhibitor (BACE-1; ER-901356; Eisai Co., Ltd., Tokyo, Japan) in TASTPM (double mutation in APP KM670/671NL and PSEN1 M146V) producing Alzheimer's disease (AD) amyloid neuropathology as...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aspartic Acid Endopeptidases

Share to Electrodes

Share to Electroencephalography

Share to Electromyography

Share to Presenilin-1

Share to Signal Processing, Computer-Assisted

Source

Open in PubMed Open full text

Identifiers

PMID: 33260655
DOI: 10.3390/ijms21239072
PMCID: PMC7730584

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic BACE-1 Inhibitor Administration in TASTPM Mice (APP KM670/671NL and PSEN1 M146V Mutation): An EEG Study.PMID 33260655Read ↗

Ongoing Electroencephalographic Activity Associated with Cortical Arousal in Transgenic PDAPP Mice (hAPP V717F).Semantic proximity Read ↗

Abnormal Cognition, Sleep, EEG and Brain Metabolism in a Novel Knock-In Alzheimer Mouse, PLB1Semantic proximity Read ↗

BACE1 regulates sleep–wake cycle through both enzymatic and non–enzymatic actionsSemantic proximity Read ↗

Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer's Disease: APP/PS1, 3xTgAD, and Tg2576.Semantic proximity Read ↗

Alteration of cortical EEG in mice carrying mutated human APP transgene.Semantic proximity Read ↗

Neurophysiological alterations in mice and humans carrying mutations in APP and PSEN1 genes.Semantic proximity Read ↗

Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's DiseaseSemantic proximity Read ↗

Natural age-related sleep-wake alterations onset prematurely in the Tg2576 mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology.Semantic proximity Read ↗

Multitaper Time-frequency Peak-based Longitudinal Sleep Analysis in 5XFAD Mouse ModelSemantic proximity Read ↗

β Oscillation during Slow Wave Sleep and Rapid Eye Movement Sleep in the Electroencephalogram of a Transgenic Mouse Model of Huntington’s DiseaseSemantic proximity Read ↗

Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.