Article
SreA-mediated iron regulation in Aspergillus fumigatus.
Molecular microbiology - 1 Oct 2008
Schrettl Markus, Kim H Stanley, Eisendle Martin, Kragl Claudia, Nierman William C, Heinekamp Thorsten, Werner Ernst R, Jacobsen Ilse, Illmer Paul, Yi Hyojeong, Brakhage Axel A, Haas Hubertus
Abstract excerpt
Aspergillus fumigatus, the most common airborne fungal pathogen of humans, employs two high-affinity iron uptake systems: iron uptake mediated by the extracellular siderophore triacetylfusarinine C and reductive iron assimilation. Furthermore, A. fumigatus utilizes two intracellular siderophores, ferricrocin and hydroxyferricrocin, to store iron. Siderophore biosynthesis, which is essential for virulence, is...
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