Article
Application of Created Restriction Site PCR-RFLP to Identify POT1 Gene Polymorphism.
Biochemistry. Biokhimiia - 1 Jun 2016
Wang Tuanwei, Wang Sihua, Duan Xiaoran, Feng Xiaolei, Wang Pengpeng, Yao Wu, Wu Yongjun, Feng Feifei, Yu Songcheng, Wu Yiming, Wang Wei
Abstract excerpt
Protection of telomeres protein 1 (POT1) plays pivotal roles in protection of chromosome ends and regulation of telomere length with other telomere binding proteins; its genetic polymorphisms are associated with many diseases. In this study, we explored a novel PCR-RFLP method for typing the single nucleotide polymorphism (SNP) rs1034794 of the human POT1 gene. A new restriction enzyme site was introduced into a...
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