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T3 Regulates a Human Macrophage-Derived TSH-β Splice Variant: Implications for Human Bone Biology

14 Jun 2016

Abstract excerpt

TSH and thyroid hormones (T3 and T4) are intimately involved in bone biology. We have previously reported the presence of a murine TSH-β splice variant (TSH-βv) expressed specifically in bone marrow-derived macrophages and that exerted an osteoprotective effect by inducing osteoblastogenesis. To extend this observation and its relevance to human bone biology, we set out to identify and characterize a TSH-β...

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PMID: 27300765
DOI: 10.1210/en.2015-1974

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