Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NF-κB-c-Rel in psoriasis: genetic susceptibility, immunopathogenic circuits, and emerging therapeutic opportunities.

Frontiers in immunology - 1 Jan 2026

Liu Ruiling, Wu Yujie, Jia Wenjing, Wang Enmei, Zheng Shijun J, Ruan Qingguo

Abstract excerpt

Psoriasis is a chronic, relapsing, immune-mediated inflammatory dermatosis characterized by aberrant keratinocyte hyperproliferation and prominent infiltration of inflammatory leukocytes. Among the NF-κB transcription factor family, c-Rel is the first member conclusively implicated as a psoriasis susceptibility gene, and its dysregulated expression positively correlates with clinical disease activity....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Molecular Targeted Therapy

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to NF-kappa B

Share to Proto-Oncogene Proteins c-rel

Share to Psoriasis

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 42483204
DOI: 10.3389/fimmu.2026.1849308
PMCID: PMC13385415

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NF-κB-c-Rel in psoriasis: genetic susceptibility, immunopathogenic circuits, and emerging therapeutic opportunities.PMID 42483204Read ↗

Treating psoriasis by targeting its susceptibility gene Rel.Semantic proximity Read ↗

Advances in the pathogenesis of psoriasis: from keratinocyte perspectiveSemantic proximity Read ↗

The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in MiceSemantic proximity Read ↗

Advances in Psoriasis Research: Decoding Immune Circuits and Developing Novel TherapiesSemantic proximity Read ↗

Cutting Edge: NF-κB p65 and c-Rel Control Epidermal Development and Immune Homeostasis in the SkinSemantic proximity Read ↗

Epigenetic and Transcriptional Regulatory Networks Underlying Psoriasis Pathogenesis.Semantic proximity Read ↗

Current Concepts of Psoriasis Immunopathogenesis.Semantic proximity Read ↗

Recent Update on Immunopathogenesis of PsoriasisSemantic proximity Read ↗

Psoriasis pathophysiology: current concepts of pathogenesis.Semantic proximity Read ↗

Genetic Variants of the NF-κB Pathway: Unraveling the Genetic Architecture of Psoriatic Disease.Semantic proximity Read ↗

The Spectrum of Mild to Severe Psoriasis Vulgaris Is Defined by a Common Activation of IL-17 Pathway Genes, but with Key Differences in Immune Regulatory GenesSemantic proximity Read ↗

Pathogenesis and treatment of psoriasis: exploiting pathophysiological pathways for precision medicine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.