Article
MHC-associated peptide proteomics enabling highly sensitive detection of immunogenic sequences for the development of therapeutic antibodies with low immunogenicity.
mAbs - 1 Jan 2000
Sekiguchi Nobuo, Kubo Chiyomi, Takahashi Ayako, Muraoka Kumiko, Takeiri Akira, Ito Shunsuke, Yano Mariko, Mimoto Futa, Maeda Atsuhiko, Iwayanagi Yuki, Wakabayashi Tetsuya, Takata Shotaro, Murao Naoaki, Chiba Shuichi, Ishigai Masaki
Abstract excerpt
Immunogenicity is a key factor capable of influencing the efficacy and safety of therapeutic antibodies. A recently developed method called MHC-associated peptide proteomics (MAPPs) uses liquid chromatography/mass spectrometry to identify the peptide sequences derived from a therapeutic protein that are presented by major histocompatibility complex class II (MHC II) on antigen-presenting cells, and therefore may...
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