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Article

A rapid and efficient strategy to generate allele-specific anti-HLA monoclonal antibodies.

Journal of immunological methods - 31 Mar 2009

Yamazaki Satoshi, Suzuki Nao, Saito Tsuneyoshi, Ishii Yumiko, Takiguchi Masafumi, Nakauchi Hiromitsu, Watanabe Nobukazu

Abstract excerpt

That generation of allele-specific anti-human leukocyte antigen (HLA) monoclonal antibodies (ASHmAb) is very difficult is well known. This is thought to be due to the unique epitope structure, an assemblage of amino acid residues that lie separately in the amino acid sequence of human HLA, and to its low antigenicity compared with that of common epitopes recognized as xenogeneic determinants by mice. Here we...

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Identifiers

PMID: 19187783
DOI: 10.1016/j.jim.2009.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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