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Article

A novel functional polymorphism of GSTM3 reduces clear cell renal cell carcinoma risk through enhancing its expression by interfering miR-556 binding.

Journal of cellular and molecular medicine - 1 Jun 2018

Wang Ying, Yang Zi-Ying, Chen Yi-Huan, Li Feng, Shen Han, Yu You, Huang Hao-Yue, Shen Zhen-Ya

Abstract excerpt

Dysregulation of glutathione-S-transferase M3 (GSTM3) has been related to clear cell renal cell carcinoma (ccRCC) in our former study. GSTM3 plays a pivotal role of detoxification and clearance of reactive oxygen species (ROS) in tumour tissues. This study aimed to examine: (1) the associations between GSTM3 single nucleotide polymorphisms (SNPs) and risk of ccRCC, and (2) the potential molecular mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29569387
DOI: 10.1111/jcmm.13528
PMCID: PMC5980204

Genes

GSTM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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