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Article

Glycosynthase Mutants of Endoglycosidase S2 Show Potent Transglycosylation Activity and Remarkably Relaxed Substrate Specificity for Antibody Glycosylation Remodeling.

The Journal of biological chemistry - 5 Aug 2016

Li Tiezheng, Tong Xin, Yang Qiang, Giddens John P, Wang Lai-Xi

Abstract excerpt

Glycosylation can exert a profound impact on the structures and biological functions of antibodies. Glycosylation remodeling using the endoglycosidase-catalyzed deglycosylation and transglycosylation approach is emerging as a promising platform to produce homogeneous glycoforms of antibodies, but the broad application of this method will require the availability of highly efficient glycosynthase mutants. We...

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Identifiers

PMID: 27288408
DOI: 10.1074/jbc.M116.738765
PMCID: PMC4974367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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