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Article

The effect of PNPLA3 polymorphism as gain in function mutation in the pathogenesis of non-alcoholic fatty liver disease.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology - 1 Feb 2020

Delik Anıl, Akkız Hikmet, Dinçer Sadık

Abstract excerpt

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is often associated with metabolic syndrome (type 2 diabetes, hypertension, hypertriglyceridemia, insulin resistance, and obesity). NAFLD is multi-factorial in pathogenesis with some genetic predisposition. The variant patatin-like phospholipase domain-containing protein 3 (PNPLA3) is known to be an independent risk factor for hepatocellular cancer (HCC). The...

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PMID: 32333362
DOI: 10.1007/s12664-020-01026-x

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