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Article

Association study of PNPLA2 gene with histological parameters of NAFLD in an obese population.

Clinics and research in hepatology and gastroenterology - 1 Jun 2016

Zegers Doreen, Verrijken An, Beckers Sigri, Francque Sven, Van Camp Jasmijn K, Aerts Evi, Ruppert Martin, Hubens Guy, Michielsen Peter, Van Hul Wim, Van Gaal Luc F

Abstract excerpt

INTRODUCTION: The prevalence of non-alcoholic fatty liver disease (NAFLD) and the closely associated metabolic syndrome is high and is related to risk factors such as obesity and type 2 diabetes. A genetic basis for NAFLD has been suggested, but only few causal genes have been identified. The most significant association reported to date is the robust association of the PNPLA3 I148M variant with susceptibility to...

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Source

Identifiers

PMID: 26500201
DOI: 10.1016/j.clinre.2015.09.001

Genes

PNPLA2
PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association study of PNPLA2 gene with histological parameters of NAFLD in an obese population.PMID 26500201Read ↗

A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population.Semantic proximity Read ↗

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Correlations between PNPLA3 Gene Polymorphisms and NAFLD in Type 2 Diabetic Patients.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.Semantic proximity Read ↗

I148M variant of PNPLA3 increases the susceptibility to non-alcoholic fatty liver disease caused by obesity and metabolic disorders.Semantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

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