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Article

Clonal evolution in relapsed and refractory diffuse large B-cell lymphoma is characterized by high dynamics of subclones.

Oncotarget - 9 Aug 2016

Melchardt Thomas, Hufnagl Clemens, Weinstock David M, Kopp Nadja, Neureiter Daniel, Tränkenschuh Wolfgang, Hackl Hubert, Weiss Lukas, Rinnerthaler Gabriel, Hartmann Tanja N, Greil Richard, Weigert Oliver, Egle Alexander

Abstract excerpt

Little information is available about the role of certain mutations for clonal evolution and the clinical outcome during relapse in diffuse large B-cell lymphoma (DLBCL). Therefore, we analyzed formalin-fixed-paraffin-embedded tumor samples from first diagnosis, relapsed or refractory disease from 28 patients using next-generation sequencing of the exons of 104 coding genes. Non-synonymous mutations were present...

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Share to Aged, 80 and over
Share to Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mutation Rate

Share to Neoplasm Recurrence, Local

Share to Treatment Failure

Share to Young Adult

Source

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Identifiers

PMID: 27285986
DOI: 10.18632/oncotarget.9860
PMCID: PMC5239491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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