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Article

An update on metabolism studies using human hepatocytes in primary culture

1 Jul 2008

Abstract excerpt

BACKGROUND: Cultured human hepatocytes are the closest in vitro model to human liver and constitute a very predictive model for drug metabolism in vivo. The variability observed in human hepatocytes reflects the existing phenotypic heterogeneity of cytochrome P450 expression in human liver. OBJECTIVES: As drug metabolism is the major source of pharmacokinetic variability in human beings, the main areas of current...

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PMID: 18624674
DOI: 10.1517/17425255.4.7.837

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