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Article

The orthopedic characterization of cfap298tm304 mutants validate zebrafish to faithfully model human AIS.

Scientific reports - 1 Apr 2021

Marie-Hardy Laura, Cantaut-Belarif Yasmine, Pietton Raphaël, Slimani Lotfi, Pascal-Moussellard Hugues

Abstract excerpt

Cerebrospinal fluid (CSF) circulation relies on the beating of motile cilia projecting in the lumen of the brain and spinal cord cavities Mutations in genes involved in cilia motility disturb cerebrospinal fluid circulation and result in scoliosis-like deformities of the spine in juvenile zebrafish. However, these defects in spine alignment have not been validated with clinical criteria used to diagnose...

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Identifiers

PMID: 33795825
DOI: 10.1038/s41598-021-86856-1
PMCID: PMC8016992

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