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Article

Genomic <i>EWSR1</i> Fusion Sequence as Highly Sensitive and Dynamic Plasma Tumor Marker in Ewing Sarcoma

9 Jun 2016

Abstract excerpt

PURPOSE: The application of the tumor-specific genomic fusion sequence as noninvasive biomarker for therapy monitoring in Ewing sarcoma (EwS) has been evaluated. EXPERIMENTAL DESIGN: EwS xenograft mouse models were used to explore detectability in small plasma volumes and correlation of genomic EWSR1-FLI1 copy numbers with tumor burden. Furthermore, 234 blood samples from 20 EwS patients were analyzed before and...

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PMID: 27283964
DOI: 10.1158/1078-0432.ccr-15-3028

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