Article
A functional variant (-1304T>G) in the MKK4 promoter contributes to a decreased risk of lung cancer by increasing the promoter activity.
Carcinogenesis - 1 Aug 2010
Liu Bin, Chen Dianke, Yang Lei, Li Yinyan, Ling Xiaoxuan, Liu Lin, Ji Weidong, Wei Yisheng, Wang Jianping, Wei Qingyi, Wang Lei, Lu Jiachun
Abstract excerpt
Mitogen-activated protein kinase kinase 4 (MKK4) is a critical mediator of stress-activated protein kinase signals that regulate apoptosis, inflammations and tumorigenesis. Several polymorphisms have been identified in the MKK4 gene. We hypothesized that genetic variants in the MKK4 promoter may alter its expression and thus cancer risk. In a case-control study of 1056 lung cancer cases and 1056 sex and age...
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