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Article

Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2016

Oe Yuji, Hayashi Sakiko, Fushima Tomofumi, Sato Emiko, Kisu Kiyomi, Sato Hiroshi, Ito Sadayoshi, Takahashi Nobuyuki

Abstract excerpt

OBJECTIVE: The role of hypercoagulability in the pathogenesis of diabetic nephropathy (DN) remains elusive. We recently reported the increased infiltration of macrophages expressing tissue factor in diabetic kidney glomeruli; tissue factor activates coagulation factor X (FX) to FXa, which in turn stimulates protease-activated receptor 2 (PAR2) and causes inflammation. APPROACH AND RESULTS: Here, we demonstrated...

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Identifiers

PMID: 27283743
DOI: 10.1161/ATVBAHA.116.307883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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