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IGFBP2 and IGFBP4 interact to activate complement pathway in diabetic kidney disease

13 Jan 2025

Abstract excerpt

BACKGROUND: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease globally. Recent research has identified insulin-like growth factor-binding proteins 2 (IGFBP2) and 4 (IGFBP4) as potential biomarkers for DKD. Overactivation of the complement pathway in DKD remains poorly understood. METHODS: experiments to investigate the roles of IGFBP2, IGFBP4, and the complement pathway in DKD. RESULTS:...

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Share to Chronic Kidney Disease and Diabetes
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PMID: 39806768
DOI: 10.1080/0886022x.2024.2440528

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