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Article

SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms.

Acta biotheoretica - 1 Sept 2016

Bizzarri Mariano, Cucina Alessandra

Abstract excerpt

The Somatic Mutation Theory (SMT) has been challenged on its fundamentals by the Tissue Organization Field Theory of Carcinogenesis (TOFT). However, a recent publication has questioned whether TOFT could be a valid alternative theory of carcinogenesis to that presented by SMT. Herein we critically review arguments supporting the irreducible opposition between the two theoretical approaches by highlighting...

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PMID: 27283400
DOI: 10.1007/s10441-016-9281-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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