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Article

SMT or TOFT? How the two main theories of carcinogenesis are made (artificially) incompatible.

Acta biotheoretica - 1 Sept 2015

Bedessem Baptiste, Ruphy Stéphanie

Abstract excerpt

The building of a global model of carcinogenesis is one of modern biology's greatest challenges. The traditional somatic mutation theory (SMT) is now supplemented by a new approach, called the Tissue Organization Field Theory (TOFT). According to TOFT, the original source of cancer is loss of tissue organization rather than genetic mutations. In this paper, we study the argumentative strategy used by the...

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PMID: 25851566
DOI: 10.1007/s10441-015-9252-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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