Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory.

Biomolecules - 30 Apr 2022

Monti Noemi, Verna Roberto, Piombarolo Aurora, Querqui Alessandro, Bizzarri Mariano, Fedeli Valeria

Abstract excerpt

The currently accepted theory on the influence of DNA mutations on carcinogenesis (the Somatic Mutation Theory, SMT) is facing an increasing number of controversial results that undermine the explanatory power of mutated genes considered as "causative" factors. Intriguing results have demonstrated that several critical genes may act differently, as oncogenes or tumor suppressors, while phenotypic reversion of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to DNA
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms

Share to Oncogenes

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 35625590
DOI: 10.3390/biom12050662
PMCID: PMC9138429

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paradoxical Behavior of Oncogenes Undermines the Somatic Mutation Theory.PMID 35625590Read ↗

Somatic mutation theory of carcinogenesis: why it should be dropped and replaced.Semantic proximity Read ↗

Molecular theory of cancer.Semantic proximity Read ↗

Towards a systemic paradigm in carcinogenesis: linking epigenetics and genetics.Semantic proximity Read ↗

Tumor and the microenvironment: a chance to reframe the paradigm of carcinogenesis?Semantic proximity Read ↗

The somatic mutation theory of cancer: growing problems with the paradigm?Semantic proximity Read ↗

Somatic Mutation Theory - Why it's Wrong for Most Cancers.Semantic proximity Read ↗

Real world in cancer? Epistemology of the origin of cancer: new paradigm for the majority of cancersSemantic proximity Read ↗

Changing mutational and adaptive landscapes and the genesis of cancer.Semantic proximity Read ↗

Cancer as a global health crisis with deep evolutionary rootsSemantic proximity Read ↗

Oncogene-induced remodelling of cellular networksSemantic proximity Read ↗

[The cause of cancer mutations: Improvable bad life or inevitable stochastic replication errors?]Semantic proximity Read ↗

The tumour microenvironment as an integrated framework to understand cancer biologySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.