Prevalence of resistance-associated substitutions and retreatment of patients failing a glecaprevir/pibrentasvir regimen.

doi:10.1093/jac/dkaa304

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Article

Prevalence of resistance-associated substitutions and retreatment of patients failing a glecaprevir/pibrentasvir regimen.

The Journal of antimicrobial chemotherapy - 1 Nov 2020

de Salazar Adolfo, Dietz Julia, di Maio Velia Chiara, Vermehren Johannes, Paolucci Stefania, Müllhaupt Beat, Coppola Nicola, Cabezas Joaquín, Stauber Rudolf E, Puoti Massimo, Arenas Ruiz Tapiador Juan Ignacio, Graf Christiana, Aragri Marianna, Jimenez Miguel, Callegaro Annapaola, Pascasio Acevedo Juan Manuel, Macias Rodriguez Manuel Alberto, Rosales Zabal Jose Miguel, Micheli Valeria, Garcia Del Toro Miguel, Téllez Francisco, García Federico, Sarrazin Christoph, Ceccherini-Silberstein Francesca

Abstract excerpt

OBJECTIVES: To investigate resistance-associated substitutions (RASs) as well as retreatment efficacies in a large cohort of European patients with failure of glecaprevir/pibrentasvir. METHODS: Patients were identified from three European Resistance Reference centres in Spain, Italy and Germany. Sequencing of NS3, NS5A and NS5B was conducted and substitutions associated with resistance to direct antiviral agents...

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PMID: 32772078
DOI: 10.1093/jac/dkaa304

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