Article
LASS5 Interacts with SDHB and Synergistically Represses p53 and p21 Activity.
Current molecular medicine - 1 Jan 2016
Jiang Z, Li F, Wan Y, Han Z, Yuan W, Cao L, Deng Y, Peng X, Chen F, Fan X, Liu X, Dai G, Wang Y, Zeng Q, Shi Y, Zhou Z, Chen Y, Xu W, Luo S, Chen S, Ye X, Mo X, Wu X, Li Y
Abstract excerpt
Longevity Assurance 5 (LASS5), a member of the LASS/Ceramide Synthases family, synthesizes C16-ceramide and is implicated in tumor biology. However, its precise role is not yet well understood. A yeast two-hybrid screen was performed using a human cDNA library to identify potential LASS5- interaction partners. One identified clone encodes succinate dehydrogenase subunit B (SDHB). Mammalian two-hybrid assays...
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