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Article

Instability of succinate dehydrogenase in SDHD polymorphism connects reactive oxygen species production to nuclear and mitochondrial genomic mutations in yeast.

Antioxidants & redox signaling - 1 Mar 2015

Chang Ya-Lan, Hsieh Meng-Hsun, Chang Wei-Wen, Wang Hurng-Yi, Lin Mei-Chun, Wang Cheng-Ping, Lou Pei-Jen, Teng Shu-Chun

Abstract excerpt

AIMS: Mitochondrial succinate dehydrogenase (SDH) is an essential complex of the electron transport chain and tricarboxylic acid cycle. Mutations in the human SDH subunit D frequently lead to paraganglioma (PGL), but the mechanistic consequences of the majority of SDHD polymorphisms have yet to be unraveled. In addition to the originally discovered yeast SDHD subunit Sdh4, a conserved homolog, Shh4, has recently...

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Source

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Identifiers

PMID: 25328978
DOI: 10.1089/ars.2014.5966
PMCID: PMC4334101

Genes

SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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