Article
On the Minimum Error Correction Problem for Haplotype Assembly in Diploid and Polyploid Genomes.
Journal of computational biology : a journal of computational molecular cell biology - 1 Sept 2016
Bonizzoni Paola, Dondi Riccardo, Klau Gunnar W, Pirola Yuri, Pisanti Nadia, Zaccaria Simone
Abstract excerpt
In diploid genomes, haplotype assembly is the computational problem of reconstructing the two parental copies, called haplotypes, of each chromosome starting from sequencing reads, called fragments, possibly affected by sequencing errors. Minimum error correction (MEC) is a prominent computational problem for haplotype assembly and, given a set of fragments, aims at reconstructing the two haplotypes by applying...
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