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Article

HapTree: a novel Bayesian framework for single individual polyplotyping using NGS data.

PLoS computational biology - 1 Mar 2014

Berger Emily, Yorukoglu Deniz, Peng Jian, Berger Bonnie

Abstract excerpt

As the more recent next-generation sequencing (NGS) technologies provide longer read sequences, the use of sequencing datasets for complete haplotype phasing is fast becoming a reality, allowing haplotype reconstruction of a single sequenced genome. Nearly all previous haplotype reconstruction studies have focused on diploid genomes and are rarely scalable to genomes with higher ploidy. Yet computational...

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PMID: 24675685
DOI: 10.1371/journal.pcbi.1003502
PMCID: PMC3967924

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