Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TGF-β1, in association with the increased expression of connective tissue growth factor, induce the hypertrophy of the ligamentum flavum through the p38 MAPK pathway.

International journal of molecular medicine - 1 Aug 2016

Cao Yan-Lin, Duan Yang, Zhu Li-Xin, Zhan Ye-Nan, Min Shao-Xiong, Jin An-Min

Abstract excerpt

Hypertrophy of the ligamentum flavum (LF) is one of the key pathomechanisms of lumbar spinal stenosis (LSS). Transforming growth factor (TGF)-β1 is abundantly expressed in hypertrophied degenerative LF tissues from LSS. However, the molecular mechanisms underling the association between TGF-β1 and LF hypertrophy have not yet been fully elucidated. In this study, we investigated the important role of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type I
Share to Collagen Type III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Connective Tissue Growth Factor

Share to Extracellular Signal-Regulated MAP Kinases

Share to Hypertrophy

Share to JNK Mitogen-Activated Protein Kinases

Share to Lumbar Vertebrae

Share to p38 Mitogen-Activated Protein Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 27279555
DOI: 10.3892/ijmm.2016.2631
PMCID: PMC4935458

Genes

LSS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TGF-β1, in association with the increased expression of connective tissue growth factor, induce the hypertrophy of the ligamentum flavum through the p38 MAPK pathway.PMID 27279555Read ↗

CRLF1 Is a Key Regulator in the Ligamentum Flavum HypertrophySemantic proximity Read ↗

MicroRNA-221 Regulates Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis by Targeting TIMP-2Semantic proximity Read ↗

TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavumSemantic proximity Read ↗

Immune cell infiltration and the genes associated with ligamentum flavum hypertrophy: Identification and validationSemantic proximity Read ↗

Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-beta1.Semantic proximity Read ↗

Isolation of Mesenchymal Stem Cells From Human Ligamentum FlavumSemantic proximity Read ↗

Dysregulation of MicroRNAs in Hypertrophy and Ossification of Ligamentum Flavum: New Advances, Challenges, and Potential DirectionsSemantic proximity Read ↗

SIRT6 enhances telomerase activity to protect against DNA damage and senescence in hypertrophic ligamentum flavum cells from lumbar spinal stenosis patientsSemantic proximity Read ↗

Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum FlavumSemantic proximity Read ↗

Development of an in vitro 3D model for investigating ligamentum flavum hypertrophySemantic proximity Read ↗

Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.Semantic proximity Read ↗

Single‐cell RNA sequencing reveals the CRTAC1 + population actively contributes to the pathogenesis of spinal ligament degeneration by SPP1 + macrophageSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.