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Article

CRLF1 Is a Key Regulator in the Ligamentum Flavum Hypertrophy

18 Sept 2020

Abstract excerpt

Hypertrophy of the ligamentum flavum (HLF) is one of the common causes of lumbar spinal stenosis (LSS). The key molecules and mechanisms responsible for HLF remain unclear. Here, we used an integrated transcriptome and proteomics analysis of human ligamentum flavum (LF), and subsequent immunohistochemistry and real-time PCR assays, to show upregulation of CRLF1 to be the dominant response to HLF. TGF-β1...

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PMID: 33072735
DOI: 10.3389/fcell.2020.00858

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