Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-beta1.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Nov 2002

Nakatani Tetsuya, Marui Takashi, Hitora Toshiaki, Doita Minoru, Nishida Kotaro, Kurosaka Masahiro

Abstract excerpt

Although mechanical stress as a result of spinal instability is known to cause hypertrophy of the ligamentum flavum resulting in degenerative spinal canal stenosis, the mechanism of the ligament hypertrophy is not well understood. In the present study, we investigated the effect of mechanical stretching force on collagen synthesis and transforming growth factor-beta1 (TGF-beta1) production using ligament cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Collagen

Share to Gene Expression

Share to Stress, Mechanical

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta1

Source

Identifiers

PMID: 12472256
DOI: 10.1016/S0736-0266(02)00046-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-beta1.PMID 12472256Read ↗

TGF-β1, in association with the increased expression of connective tissue growth factor, induce the hypertrophy of the ligamentum flavum through the p38 MAPK pathway.Semantic proximity Read ↗

Isolation of Mesenchymal Stem Cells From Human Ligamentum FlavumSemantic proximity Read ↗

Development of an in vitro 3D model for investigating ligamentum flavum hypertrophySemantic proximity Read ↗

CRLF1 Is a Key Regulator in the Ligamentum Flavum HypertrophySemantic proximity Read ↗

MicroRNA-221 Regulates Hypertrophy of Ligamentum Flavum in Lumbar Spinal Stenosis by Targeting TIMP-2Semantic proximity Read ↗

Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum FlavumSemantic proximity Read ↗

Mechanical strain applied to human fibroblasts differentially regulates skeletal myoblast differentiationSemantic proximity Read ↗

Contemporary views on the ossification of the ligamenta flava.Semantic proximity Read ↗

TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavumSemantic proximity Read ↗

Collagen in tendon, ligament, and bone healing. A current review.Semantic proximity Read ↗

Ligament-derived matrix stimulates a ligamentous phenotype in human adipose-derived stem cells.Semantic proximity Read ↗

Ossification process involving the human thoracic ligamentum flavum: role of transcription factorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.