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Article

TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavum

12 Oct 2022

Abstract excerpt

BACKGROUND: Hypertrophy of ligamentum flavum (HLF) is the mainly cause of lumbar spinal stenosis (LSS), but the precise mechanism of HLF formation has not been fully elucidated. Emerging evidence indicates that transcription factor 7 (TCF7) is the key downstream functional molecule of Wnt/β-catenin signaling, which participated in regulating multiple biological processes. However, the role and underlying...

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PMID: 36224570
DOI: 10.1186/s12967-022-03677-0

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TCF7/SNAI2/miR-4306 feedback loop promotes hypertrophy of ligamentum flavumPMID 36224570Read ↗

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