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Article

Integrative analysis of genome-wide DNA methylation and single-nucleotide polymorphism identified ACSM5 as a suppressor of lumbar ligamentum flavum hypertrophy.

Arthritis research & therapy - 30 Sept 2021

Cao Yanlin, Zhan Yenan, Qiu Sujun, Chen Zhong, Gong Kaiqin, Ni Songjia, Duan Yang

Abstract excerpt

BACKGROUND: Hypertrophy of ligamentum flavum (HLF) is a common lumbar degeneration disease (LDD) with typical symptoms of low back pain and limb numbness owing to an abnormal pressure on spinal nerves. Previous studies revealed HLF might be caused by fibrosis, inflammatory, and other bio-pathways. However, a global analysis of HLF is needed severely. METHODS: A genome-wide DNA methylation and single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34593020
DOI: 10.1186/s13075-021-02625-5
PMCID: PMC8482693

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