Cytochrome P450 genes in coronary artery diseases: Codon usage analysis reveals genomic GC adaptation.

doi:10.1016/j.gene.2016.06.011

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Article

Cytochrome P450 genes in coronary artery diseases: Codon usage analysis reveals genomic GC adaptation.

Gene - 15 Sept 2016

Malakar Arup Kumar, Halder Binata, Paul Prosenjit, Chakraborty Supriyo

Abstract excerpt

Establishing codon usage biases are imperative for understanding the etiology of coronary artery diseases (CAD) as well as the genetic factors associated with these diseases. The aim of this study was to evaluate the contribution of 18 responsible cytochrome P450 (CYP) genes for the risk of CAD. Effective number of codon (Nc) showed a negative correlation with both GC3 and synonymous codon usage order (SCUO)...

Topics

Adaptation, Physiological
Base Composition
Codon
Coronary Artery Disease
Cytochrome P-450 Enzyme System
Gene Expression
Humans
Isoenzymes
Mutation
Principal Component Analysis
Selection, Genetic

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PMID: 27275533
DOI: 10.1016/j.gene.2016.06.011

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