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Article

Molecular determinants of prokaryotic voltage-gated sodium channels for recognition of local anesthetics.

The FEBS journal - 1 Aug 2016

Shimomura Takushi, Irie Katsumasa, Fujiyoshi Yoshinori

Abstract excerpt

Local anesthetics (LAs) inhibit mammalian voltage-gated Na(+) channels (Navs) and are thus clinically important. LAs also inhibit prokaryotic Navs (BacNavs), which have a simpler structure than mammalian Navs. To elucidate the detailed mechanisms of LA inhibition to BacNavs, we used NavBh, a BacNav from Bacillus halodurans, to analyze the interactions of several LAs and quaternary ammoniums (QAs). Based on the...

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Identifiers

PMID: 27273848
DOI: 10.1111/febs.13776

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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