Article
Burkholderia mallei CLH001 Attenuated Vaccine Strain Is Immunogenic and Protects against Acute Respiratory Glanders.
Infection and immunity - 1 Aug 2016
Hatcher Christopher L, Mott Tiffany M, Muruato Laura A, Sbrana Elena, Torres Alfredo G
Abstract excerpt
Burkholderia mallei is the causative agent of glanders, an incapacitating disease with high mortality rates in respiratory cases. Its endemicity and ineffective treatment options emphasize its public health threat and highlight the need for a vaccine. Live attenuated vaccines are considered the most viable vaccine strategy for Burkholderia, but single-gene-deletion mutants have not provided complete protection....
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