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Article

Characterization of clinically-attenuated Burkholderia mallei by whole genome sequencing: candidate strain for exclusion from Select Agent lists.

PloS one - 30 Apr 2008

Schutzer Steven E, Schlater Linda R K, Ronning Catherine M, DeShazer David, Luft Benjamin J, Dunn John J, Ravel Jacques, Fraser-Liggett Claire M, Nierman William C

Abstract excerpt

BACKGROUND: Burkholderia mallei is an understudied biothreat agent responsible for glanders which can be lethal in humans and animals. Research with this pathogen has been hampered in part by constraints of Select Agent regulations for safety reasons. Whole genomic sequencing (WGS) is an apt approach to characterize newly discovered or poorly understood microbial pathogens. METHODOLOGY/PRINCIPAL FINDINGS: We...

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PMID: 18446194
DOI: 10.1371/journal.pone.0002058
PMCID: PMC2312325

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