Article
Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation.
Oncotarget - 28 Jun 2016
Christiansen Ailsa J, Dieterich Lothar C, Ohs Isabel, Bachmann Samia B, Bianchi Roberta, Proulx Steven T, Hollmén Maija, Aebischer David, Detmar Michael
Abstract excerpt
Vascular endothelial growth factor-C (VEGF-C)-induced lymphangiogenesis and increased tissue drainage have been reported to inhibit acute and chronic inflammation, and an activated lymphatic endothelium might mediate peripheral tolerance. Using transgenic mice overexpressing VEGF-C in the skin, we found that under inflammatory conditions, VEGF-C-mediated expansion of the cutaneous lymphatic network establishes an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.