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Article

Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4.

PloS one - 1 Jan 2017

Volk-Draper Lisa D, Hall Kelly L, Wilber Andrew C, Ran Sophia

Abstract excerpt

BACKGROUND: Myeloid-derived lymphatic endothelial cells (M-LECP) are induced by inflammation and play an important role in adult lymphangiogenesis. However, the mechanisms driving M-LECP differentiation are currently unclear. We previously showed that activation of Toll-like receptor-4 (TLR4) induces myeloid-lymphatic transition (MLT) of immortalized mouse myeloid cells. Here the goals were to assess the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28598999
DOI: 10.1371/journal.pone.0179257
PMCID: PMC5466303

Genes

TLR4
HMGB1
PDPN
PROX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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