Article
Chemotherapy-Induced Neurotoxicity: Evidence of a Protective Role of CC Homozygosis in the Interleukin-1β Gene-511 C>T Polymorphism.
Neurotoxicity research - 1 Oct 2016
Peila E, D'Agata F, Caroppo P, Orsi L, Mortara P, Cauda S, Manfredi M, Caglio M M, Fenoglio P, Baudino B, Castellano G, Bisi G, Pinessi L, Gallone S
Abstract excerpt
We hypothesized that the IL-1β-511 C>T polymorphism could be associated with the development of neurotoxicity and that it could be a possible biomarker to rate the risk of occurrence of neurotoxicity in cancer patients. Genomic DNA was extracted from 85 cancer patients: 49 received systemic chemotherapeutic treatment (CHT) and 36 patients did not receive it (No-CHT). All subjects were genotyped for the...
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