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Article

Cytokine-mediated blood brain barrier disruption as a conduit for cancer/chemotherapy-associated neurotoxicity and cognitive dysfunction.

International journal of cancer - 15 Dec 2016

Wardill Hannah R, Mander Kimberley A, Van Sebille Ysabella Z A, Gibson Rachel J, Logan Richard M, Bowen Joanne M, Sonis Stephen T

Abstract excerpt

Neurotoxicity is a common side effect of chemotherapy treatment, with unclear molecular mechanisms. Clinical studies suggest that the most frequent neurotoxic adverse events affect memory and learning, attention, concentration, processing speeds and executive function. Emerging preclinical research points toward direct cellular toxicity and induction of neuroinflammation as key drivers of neurotoxicity and...

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PMID: 27367824
DOI: 10.1002/ijc.30252

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