Article
In Vitro Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539.
Antimicrobial agents and chemotherapy - 1 Aug 2016
Patel Hetalkumar D, Nikitin Pavel, Gesner Thomas, Lin James J, Barkan David T, Ciferri Claudio, Carfi Andrea, Akbarnejad Yazdi Tahmineh, Skewes-Cox Peter, Wiedmann Brigitte, Jarousse Nadine, Zhong Weidong, Feire Adam, Hebner Christy M
Abstract excerpt
Human cytomegalovirus (HCMV) infection is usually benign in healthy individuals but can cause life-threatening disease in those with compromised immune systems. Approved drugs available to treat HCMV disease, including ganciclovir, cidofovir, and foscarnet, have significant toxicities that limit their use in certain patient populations. LJP538 and LJP539 are human monoclonal antibodies that are being evaluated as...
Topics
- Antibodies, Monoclonal
- Antibodies, Neutralizing
- Antibodies, Viral
- Antiviral Agents
- Cell Line
- Cytomegalovirus
- Cytomegalovirus Infections
- Humans
- Membrane Glycoproteins