Article
Nemonoxacin Enhances Antibacterial Activity and Anti-Resistance Mutation Ability of Vancomycin against Methicillin-Resistant Staphylococcus aureus in an In Vitro Dynamic Pharmacokinetic/Pharmacodynamic Model.
Antimicrobial agents and chemotherapy - 15 Feb 2022
Huang Junchen, Guo Siwei, Li Xin, Yuan Fang, Li You, Xu Bing, Gu Junyuan, Qiao Yong
Abstract excerpt
Reduced susceptibility and emergence of resistance to vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) have led to the development of various vancomycin-based combinations. Nemonoxacin is a novel nonfluorinated quinolone with antibacterial activity against MRSA. The present study aimed to investigate the effects of nemonoxacin on antibacterial activity and the anti-resistant mutation ability of...
Topics
- Anti-Bacterial Agents
- Methicillin-Resistant Staphylococcus aureus
- Microbial Sensitivity Tests
- Mutation
- Quinolones
- Vancomycin
- Vancomycin Resistance