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Article

Prefrontal activity during working memory is modulated by the interaction of variation in CB1 and COX2 coding genes and correlates with frequency of cannabis use.

Cortex; a journal devoted to the study of the nervous system and behavior - 1 Aug 2016

Taurisano Paolo, Antonucci Linda A, Fazio Leonardo, Rampino Antonio, Romano Raffaella, Porcelli Annamaria, Masellis Rita, Colizzi Marco, Quarto Tiziana, Torretta Silvia, Di Giorgio Annabella, Pergola Giulio, Bertolino Alessandro, Blasi Giuseppe

Abstract excerpt

The CB1 cannabinoid receptor is targeted in the brain by endocannabinoids under physiological conditions as well as by delta9-tetrahydrocannabinol under cannabis use. Furthermore, its signaling appears to affect brain cognitive processing. Recent findings highlight a crucial role of cyclooxygenase-2 (COX-2) in the mechanism of intraneuronal CB1 signaling transduction, while others indicate that two single...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetic Resonance Imaging

Share to Memory, Short-Term

Share to Polymorphism, Single Nucleotide

Share to Prefrontal Cortex

Share to Receptor, Cannabinoid, CB1

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Source

Identifiers

PMID: 27261878
DOI: 10.1016/j.cortex.2016.05.010

Genes

CNR1
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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