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Article

The Effect of ABCB1 and CES1 Polymorphisms on Plasma Levels of Dabigatran and Risk of Hemorrhagic Complications in Ischemic Stroke Patients.

American journal of therapeutics - 1 Jan 2000

Olšerová Anna, Janský Petr, Magerová Hana, Šrámková Tereza, Kešnerová Petra, Kmetonyová Silvia, Šulc Vlastimil, Halmová Hana, Šrámek Martin, Šarbochová Ivana, Paulasová-Schwabová Jaroslava, Benešová Kateřina, Macek Jan, Maťoška Václav, Tomek Aleš

Abstract excerpt

BACKGROUND: Dabigatran directly inhibits thrombin and is used in primary and secondary stroke prevention in individuals with nonvalvular atrial fibrillation. The prodrug dabigatran etexilate is absorbed by enteral P-glycoprotein (ABCB1) and then activated by hepatic and intestinal carboxylesterases (CES1) to produce active metabolites. Variations in dabigatran metabolism because of genetics may affect...

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PMID: 38525959
DOI: 10.1097/MJT.0000000000001710

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The Effect of ABCB1 and CES1 Polymorphisms on Plasma Levels of Dabigatran and Risk of Hemorrhagic Complications in Ischemic Stroke Patients.PMID 38525959Read ↗

The impact of ABCB1 and CES1 polymorphisms on dabigatran pharmacokinetics and pharmacodynamics in patients with atrial fibrillationSemantic proximity Read ↗

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The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillationSemantic proximity Read ↗

The impact of ABCB1 and CES1 polymorphisms on the safety of dabigatran in patients with non-valvular atrial fibrillationSemantic proximity Read ↗

Effect of CES1 and ABCB1 genotypes on the pharmacokinetics and clinical outcomes of dabigatran etexilate in patients with atrial fibrillation and chronic kidney disease.Semantic proximity Read ↗

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