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The Distribution of the Genotypes of ABCB1 and CES1 Polymorphisms in Kazakhstani Patients with Atrial Fibrillation Treated with DOAC.

Genes - 29 May 2023

Abdrakhmanov Ayan, Akilzhanova Ainur, Shaimerdinova Aizhan, Zhalbinova Madina, Tuyakova Gulnara, Abildinova Svetlana, Albayev Rustam, Ainabekova Bayan, Chinybayeva Assel, Suleimen Zhanasyl, Bekbossynova Makhabbat

Abstract excerpt

Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify the influence of polymorphisms of the genes encoding P-glycoprotein (ABCB1) and carboxylesterase 1 (CES1) on the variability of plasma concentrations of DOACs in Kazakhstani patients with NVAF. We analyzed polymorphisms rs4148738, rs1045642,...

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Identifiers

PMID: 37372371
DOI: 10.3390/genes14061192
PMCID: PMC10298263

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