Article
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.
Molecular psychiatry - 1 Jan 2012
Wray N R, Pergadia M L, Blackwood D H R, Penninx B W J H, Gordon S D, Nyholt D R, Ripke S, MacIntyre D J, McGhee K A, Maclean A W, Smit J H, Hottenga J J, Willemsen G, Middeldorp C M, de Geus E J C, Lewis C M, McGuffin P, Hickie I B, van den Oord E J C G, Liu J Z, Macgregor S, McEvoy B P, Byrne E M, Medland S E, Statham D J, Henders A K, Heath A C, Montgomery G W, Martin N G, Boomsma D I, Madden P A F, Sullivan P F
Abstract excerpt
Major depressive disorder (MDD) is a common complex disorder with a partly genetic etiology. We conducted a genome-wide association study of the MDD2000+ sample (2431 cases, 3673 screened controls and >1 M imputed single-nucleotide polymorphisms (SNPs)). No SNPs achieved genome-wide significance either in the MDD2000+ study, or in meta-analysis with two other studies totaling 5763 cases and 6901 controls. These...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.