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The splicing factor Sf3b1 regulates erythroid maturation and proliferation via TGFβ signaling in zebrafish

12 Jul 2019

Abstract excerpt

Abstract The spliceosomal component Splicing Factor 3B, subunit 1 (SF3B1) is one of the most prevalently mutated factors in the bone marrow failure disorder myelodysplastic syndrome. There is a strong clinical correlation between SF3B1 mutations and erythroid defects, such as refractory anemia with ringed sideroblasts, but the role of SF3B1 in normal erythroid development is largely unknown. Loss-of-function...

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PMID: 31300417
DOI: 10.1182/bloodadvances.2018027714

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