Optimized selection of unrelated subjects for whole-genome sequencing studies of rare high-penetrance alleles.

Abstract excerpt

Sequencing studies using whole-genome or exome scans are still more expensive than genome-wide association studies on a per-subject basis. As a result, only a subset of subjects from a larger study will be selected for sequencing. To perform an agnostic investigation of the entire genome, subjects may be selected that capture independent ancestral lineages, i.e., founder genomes, and thus avoid redundant...

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