Article
Extensive coronavirus-induced membrane rearrangements are not a determinant of pathogenicity.
Scientific reports - 3 Jun 2016
Maier Helena J, Neuman Benjamin W, Bickerton Erica, Keep Sarah M, Alrashedi Hasan, Hall Ross, Britton Paul
Abstract excerpt
Positive-strand RNA (+RNA) viruses rearrange cellular membranes during replication, possibly in order to concentrate and arrange viral replication machinery for efficient viral RNA synthesis. Our previous work showed that in addition to the conserved coronavirus double membrane vesicles (DMVs), Beau-R, an apathogenic strain of avian Gammacoronavirus infectious bronchitis virus (IBV), induces regions of ER that...
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