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A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis

8 Jun 2020

Abstract excerpt

Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave international public health concern. In infected cells, the CoV RNA-synthesizing machinery associates with modified endoplasmic reticulum membranes that are transformed into the viral replication organelle (RO). Although double-membrane vesicles (DMVs) appear...

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PMID: 32511245
DOI: 10.1371/journal.pbio.3000715

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